SCLC Phenospace

Interactive Fig. 3B–C from Wooten, Groves et al. (2019) PLoS Comput Biol

Region labels

10^-2 10^-5 10^-10 ≤10^-20 enrichment p

Hover a dot for the GO term; click it to see its modules. Drag to zoom.

Find a process

Pick a subtype

Selects the modules that are upregulated in that subtype.

Modules

Data: S1 File (GO t-SNE maps), S2 Table (module discrimination) and S4 Table (GSEA) of Wooten DJ, Groves SM, Tyson DR, Liu Q, Lim JS, Albert R, Lopez CF, Sage J, Quaranta V (2019). Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers. PLoS Comput Biol 15(10): e1007343. Module summaries paraphrase the paper. Region labels are the Fig. 3B labels, placed by hand; two (Ion transport, Learning) are left out because the terms under them do not match the label.

See also the Network Explorer for the SCLC transcription factor network from the same paper.